Friday 8 February 2013

CONTROL DELIVERY

polymeric micelle is a nanoparticle structure by one hydropholic shell and one hydrophobic core. it can be divide into two category :hydrophobically assembled micelles and polygon-complex micelles.
the formal one usually consist ofanphiphilic copolymers with a hydrophpbic block and a hydrophilic block balance between those two block in an aqueous medium induces spontaneous formation of nano-sized particulate.
DRUG DELIVERY SYSTEM
Abstract: In past two decades poly lactic-co-glycolic acid (PLGA) has been among the
most attractive polymeric candidates used to fabricate devices for drug delivery and tissue
engineering applications. PLGA is biocompatible and biodegradable, exhibits a wide range
of erosion times, has tunable mechanical properties and most importantly, is a FDA approved
polymer. In particular, PLGA has been extensively studied for the development of devices for
controlled delivery of small molecule drugs, proteins and other macromolecules in
commercial use and in research. This manuscript describes the various fabrication techniques
for these devices and the factors affecting their degradation and drug release.
Keywords: poly lactic-co-glycolic acid; drug delivery; PLGA degradation; sustained release;
PLGA fabrication techniques.
STRUCTURE OF A PLGA